ICD-11 code : 5B5A.1;
Preferred Label : Wernicke-Korsakoff Syndrome;
ICD-11 definition : A thiamine-deficiency syndrome characterized by symmetric hyperaemic lesions of the
brainstem, hypothalamus, thalamus, and mammillary bodies with glial proliferation,
capillary dilatation, and perivascular haemorrhage. The syndrome is manifested by
a confusional state, disorientation, ophthalmoplegia, nystagmus, diplopia, and ataxia
(Wernicke encephalopathy), with severe loss of memory for recent events and confabulation
(the invention of accounts of events to cover the loss of memory) (Korsakov psychosis)
occurring following recovery. Defective binding of thiamine diphosphate by transketolase
has been found. It appears that the disorder is of autosomal recessive inheritance
but is expressed as clinical disease only in the event of thiamine deficiency.;
ICD-11 "other" category code : 5B5A.1Y;
ICD-11 "unspecified" category code : 5B5A.1Z;
Origin ID : 2017611840;
Automatic exact mappings (from CISMeF team)
- ICD-10 Mapping
A thiamine-deficiency syndrome characterized by symmetric hyperaemic lesions of the
brainstem, hypothalamus, thalamus, and mammillary bodies with glial proliferation,
capillary dilatation, and perivascular haemorrhage. The syndrome is manifested by
a confusional state, disorientation, ophthalmoplegia, nystagmus, diplopia, and ataxia
(Wernicke encephalopathy), with severe loss of memory for recent events and confabulation
(the invention of accounts of events to cover the loss of memory) (Korsakov psychosis)
occurring following recovery. Defective binding of thiamine diphosphate by transketolase
has been found. It appears that the disorder is of autosomal recessive inheritance
but is expressed as clinical disease only in the event of thiamine deficiency.
