ICD-11 code : CA08.0;
Preferred Label : Allergic rhinitis;
ICD-11 definition : Allergic rhinitis is an inflammation of nasal airway triggered by allergens to which
the affected individual has previously been sensitized. Pathogenesis of allergic rhinitis
is type I allergy on the nasal mucosa. Antigens inhaled into sensitized nasal mucosa
bind to IgE antibodies on mast cells, which release chemical mediators such as histamine
and peptide leukotriene. Consequently terminal of sensory neurons and vessels react
to induce sneezing, running nose, and stuffy nose (immediate phase reaction). In late
phase reaction, various chemical mediators are produced by mast cells, cytokines are
produced by Th2 and mast cells, and chemokines are produced by epithelial cells, endothelium
of blood vessels, and fibrocytes, respectively. These cell-derived transmitters actually
induce various cell types of inflammatory cell infiltration to nasal mucosa. Among
them, activated eosinophils is the main player of mucosal swelling and hyperreactivity.;
ICD-11 inclusion : allergic rhinitis, cause unspecified;
ICD-11 "unspecified" category code : CA08.0Z;
Origin ID : 1711769234;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- ICD-10 Mapping
- See also inter- (CISMeF)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
Allergic rhinitis is an inflammation of nasal airway triggered by allergens to which
the affected individual has previously been sensitized. Pathogenesis of allergic rhinitis
is type I allergy on the nasal mucosa. Antigens inhaled into sensitized nasal mucosa
bind to IgE antibodies on mast cells, which release chemical mediators such as histamine
and peptide leukotriene. Consequently terminal of sensory neurons and vessels react
to induce sneezing, running nose, and stuffy nose (immediate phase reaction). In late
phase reaction, various chemical mediators are produced by mast cells, cytokines are
produced by Th2 and mast cells, and chemokines are produced by epithelial cells, endothelium
of blood vessels, and fibrocytes, respectively. These cell-derived transmitters actually
induce various cell types of inflammatory cell infiltration to nasal mucosa. Among
them, activated eosinophils is the main player of mucosal swelling and hyperreactivity.
