ICD-11 definition : Sclerema neonatorum is an uncommon condition which typically affects gravely ill,
preterm neonates in the first week of life. It manifests as a diffuse hardening of
skin and subcutaneous adipose tissue such that the skin cannot be pitted or picked
up and pinched into a fold. Histologically there is minimal inflammation without fat
necrosis. It is associated with a high mortality.;
Sclerema neonatorum is an uncommon condition which typically affects gravely ill,
preterm neonates in the first week of life. It manifests as a diffuse hardening of
skin and subcutaneous adipose tissue such that the skin cannot be pitted or picked
up and pinched into a fold. Histologically there is minimal inflammation without fat
necrosis. It is associated with a high mortality.