ICD-11 definition : X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disease characterized by progressive
demyelinisation of the central nervous system (CNS) (brain and/or spinal cord) and
peripheral adrenal insufficiency. The cerebral forms of juvenile X-ALD (45% of the
cases) affect previously healthy 5 to 12 year-old boys. The adult form, adrenomyeloneuropathy
(AMN), is characterized by the onset of spastic paraparesia between 20 and 45 years
of age, associated with gait disturbances, urinary disorders and sexual dysfunction.;
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disease characterized by progressive
demyelinisation of the central nervous system (CNS) (brain and/or spinal cord) and
peripheral adrenal insufficiency. The cerebral forms of juvenile X-ALD (45% of the
cases) affect previously healthy 5 to 12 year-old boys. The adult form, adrenomyeloneuropathy
(AMN), is characterized by the onset of spastic paraparesia between 20 and 45 years
of age, associated with gait disturbances, urinary disorders and sexual dysfunction.