Preferred Label : Palmoplantar keratoderma – oral leukokeratosis – oesophageal carcinoma;
ICD-11 definition : This condition is inherited as an autosomal dominant syndrome and characterized by
palmoplantar keratoderma, oral precursor lesions particularly on the gums (leukoplakia)
and a high lifetime risk of oesophageal cancer.;
ICD-11 synonym : Howel-Evans syndrome; Tylosis with oesophageal cancer;
This condition is inherited as an autosomal dominant syndrome and characterized by
palmoplantar keratoderma, oral precursor lesions particularly on the gums (leukoplakia)
and a high lifetime risk of oesophageal cancer.
