Preferred Label : Hereditary factor XII deficiency;
ICD-11 definition : Congenital factor XII deficiency is a systemic dysfunction of the hemostatic pathway,
inherited in an autosomal recessive manner and caused by a defect in the coagulation
factor XII (FXII or Hageman factor). Affected individuals are either asymptomatic
or present a prolonged activated partial thromboplastin time and have an increased
risk for thromboembolism (such as development of ocular vascular complications, occurring
particularly in younger people). Superficial migratory thrombophlebitis and leg ulcer
are rarely observed. FXII deficiency usually does not lead to bleeding complications
but is strongly associated with primary recurrent abortions.;
ICD-11 synonym : Congenital Hageman factor deficiency;
ICD-11 inclusion : Hageman factor defect; Hageman deficiency; factor XII deficiency disease; Hageman defect; Deficiency of factor XII; Hageman factor deficiency; congenital factor XII deficiency;
Origin ID : 2086126201;
Automatic exact mappings (from CISMeF team)
Congenital factor XII deficiency is a systemic dysfunction of the hemostatic pathway,
inherited in an autosomal recessive manner and caused by a defect in the coagulation
factor XII (FXII or Hageman factor). Affected individuals are either asymptomatic
or present a prolonged activated partial thromboplastin time and have an increased
risk for thromboembolism (such as development of ocular vascular complications, occurring
particularly in younger people). Superficial migratory thrombophlebitis and leg ulcer
are rarely observed. FXII deficiency usually does not lead to bleeding complications
but is strongly associated with primary recurrent abortions.
