Preferred Label : Paraneoplastic hyperexcitability syndrome with continuous muscle fibre activity;
ICD-11 definition : The autoimmune hyperexcitability syndrome with CMFA, is a rare neuromuscular syndrome
characterized by muscle weakness, often myokymia, CMFA, at times a cramp and fasciculation
syndrome and autonomic features. Paraesthesia and hyperhydrosis are also common. Also
CNS symptoms can be associated in Morvan's syndrome. It can appear both as an autoimmune-
and a paraneoplastic disease. An association with thymoma exists. The disease is soften
antibody mediated in particular with potassium channel antibodies ( VGKC) and the
CASPR2 and less LGII subtype. It responds to symptomatic therapy and immune therapies.;
ICD-11 synonym : Morvan syndrome;
Origin ID : 1599858362;
Automatic exact mappings (from CISMeF team)
The autoimmune hyperexcitability syndrome with CMFA, is a rare neuromuscular syndrome
characterized by muscle weakness, often myokymia, CMFA, at times a cramp and fasciculation
syndrome and autonomic features. Paraesthesia and hyperhydrosis are also common. Also
CNS symptoms can be associated in Morvan's syndrome. It can appear both as an autoimmune-
and a paraneoplastic disease. An association with thymoma exists. The disease is soften
antibody mediated in particular with potassium channel antibodies ( VGKC) and the
CASPR2 and less LGII subtype. It responds to symptomatic therapy and immune therapies.
