Preferred Label : Diffuse non-epidermolytic palmoplantar keratoderma;
ICD-11 definition : Diffuse non-epidermolytic palmoplantar keratoderma (MIM #600962 ) is an autosomal
dominant disorder caused by mutations in the keratin 1 gene. It presents in early
childhood even, very thick, yellow hyperkeratosis over the whole of the foot and spreading
later to the palms. There is a sharp cut-off at the wrist and no tendency to spread
to extensor surfaces. Hyperhidrosis is usual and dermatophyte infection is common.;
ICD-11 synonym : Unna palmoplantar keratoderma; Tylosis;
Origin ID : 1481454585;
Automatic exact mappings (from CISMeF team)
Diffuse non-epidermolytic palmoplantar keratoderma (MIM #600962 ) is an autosomal
dominant disorder caused by mutations in the keratin 1 gene. It presents in early
childhood even, very thick, yellow hyperkeratosis over the whole of the foot and spreading
later to the palms. There is a sharp cut-off at the wrist and no tendency to spread
to extensor surfaces. Hyperhidrosis is usual and dermatophyte infection is common.
