Preferred Label : Von Willebrand disease type 2M;
ICD-11 definition : Type 2M von Willebrand disease (type 2M VWD) is a subtype of type 2 VWD (see this
term) characterized by a bleeding disorder associated with a decrease in the affinity
of the Willebrand factor (von Willebrand factor; VWF) for platelets and the subendothelium
in the absence of any deficiency of high molecular weight VWF multimers. The disease
manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal
hemorrhage etc.). Type 2M VWD is caused by mutations in the VWF gene and transmission
is autosomal dominant.;
Origin ID : 1358085002;
Automatic exact mappings (from CISMeF team)
Type 2M von Willebrand disease (type 2M VWD) is a subtype of type 2 VWD (see this
term) characterized by a bleeding disorder associated with a decrease in the affinity
of the Willebrand factor (von Willebrand factor; VWF) for platelets and the subendothelium
in the absence of any deficiency of high molecular weight VWF multimers. The disease
manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal
hemorrhage etc.). Type 2M VWD is caused by mutations in the VWF gene and transmission
is autosomal dominant.
