ICD-11 code : CA08;
Preferred Label : Vasomotor or allergic rhinitis;
ICD-11 definition : Rhinitis is inflammation of the nasal mucosa clinically characterized by major symptoms:
sneezing, nasal pruritus, running nose, and stuffy nose. Allergic rhinitis is an inflammation
of nasal airway triggered by allergens to which the affected individual has previously
been sensitized. Pathogenesis of allergic rhinitis is type I allergy on the nasal
mucosa. Antigens inhaled into sensitized nasal mucosa bind to IgE antibodies on mast
cells, which release chemical mediators such as histamine and peptide leukotriene.
Consequently terminal of sensory neurons and vessels react to induce sneezing, running
nose, and stuffy nose (immediate phase reaction). In late phase reaction, various
chemical mediators are produced by mast cells, cytokines are produced by Th2 and mast
cells, and chemokines are produced by epithelial cells, endothelium of blood vessels,
and fibrocytes, respectively. These cell-derived transmitters actually induce various
cell types of inflammatory cell infiltration to nasal mucosa. Among them, activated
eosinophils is the main player of mucosal swelling and hyperreactivity. Non-allergic
rhinitis is an inflammation of nasal mucosa in which allergic mechanisms are not involved.
It covers many different phenotypes.;
ICD-11 inclusion : idiopathic rhinitis;
ICD-11 "other" category code : CA08.Y;
ICD-11 "unspecified" category code : CA08.Z;
Origin ID : 2090379743;
Automatic exact mappings (from CISMeF team)
- ICD-10 Mapping
Rhinitis is inflammation of the nasal mucosa clinically characterized by major symptoms:
sneezing, nasal pruritus, running nose, and stuffy nose. Allergic rhinitis is an inflammation
of nasal airway triggered by allergens to which the affected individual has previously
been sensitized. Pathogenesis of allergic rhinitis is type I allergy on the nasal
mucosa. Antigens inhaled into sensitized nasal mucosa bind to IgE antibodies on mast
cells, which release chemical mediators such as histamine and peptide leukotriene.
Consequently terminal of sensory neurons and vessels react to induce sneezing, running
nose, and stuffy nose (immediate phase reaction). In late phase reaction, various
chemical mediators are produced by mast cells, cytokines are produced by Th2 and mast
cells, and chemokines are produced by epithelial cells, endothelium of blood vessels,
and fibrocytes, respectively. These cell-derived transmitters actually induce various
cell types of inflammatory cell infiltration to nasal mucosa. Among them, activated
eosinophils is the main player of mucosal swelling and hyperreactivity. Non-allergic
rhinitis is an inflammation of nasal mucosa in which allergic mechanisms are not involved.
It covers many different phenotypes.
