ICD-11 code : 2C12;
Preferred Label : Malignant neoplasms of liver or intrahepatic bile ducts;
ICD-11 definition : The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma
(HCC). In many parts of the world, in particular Africa and Asia, it poses a significant
disease burden. In these high incidence regions, chronic infection with hepatitis
B virus (HBV) is the principal underlying cause, with the exception of Japan which
has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful
tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several
high risk regions. In Western countries, chronic alcohol abuse is a major aetiological
factor. Hepatic cholangiocarcinoma has a different geographical distribution, with
peak incidences in Northern Thailand. Here, it is caused by chronic infection with
the liver fluke, Opisthorchis Viverrini, which is ingested through infected raw fish.;
ICD-11 "unspecified" category code : 2C12.Z;
Origin ID : 1404966610;
UMLS CUI : C0153448;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- ICD-10 Mapping
- Semantic type(s)
- UMLS correspondences (same concept)
The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma
(HCC). In many parts of the world, in particular Africa and Asia, it poses a significant
disease burden. In these high incidence regions, chronic infection with hepatitis
B virus (HBV) is the principal underlying cause, with the exception of Japan which
has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful
tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several
high risk regions. In Western countries, chronic alcohol abuse is a major aetiological
factor. Hepatic cholangiocarcinoma has a different geographical distribution, with
peak incidences in Northern Thailand. Here, it is caused by chronic infection with
the liver fluke, Opisthorchis Viverrini, which is ingested through infected raw fish.
