_____
Citation 1
Authors
Roussel S. Courville P. Peron JM. Delcampe P. Metayer J.
Title
[Oral aphthae induced by nicorandil. Anatomopathologic aspects. Apropos of a
case]. [French]
Original Title
Aphtose buccale induite par le nicorandil. Aspect anatomopathologique. A
propos d'un cas.
Source
Revue de Stomatologie et de Chirurgie Maxillo-Faciale. 99(4):207-9, 1998
Nov.
Abstract
Major apthous stomatitis induced by nicorandil is exceptional, the mechanism
is still unknown and the histological aspect of these lesions have not been
previously reported. Our case reports a man who was treated by nicorandil
for coronary artery disease. He was referred for major aphtous stomatitis;
one element was biopsied. The histological aspect was an aspecific
sialadenitis, with granulous reaction, and without vasculitis or
eosinophilic infiltration. We conclude that aphtous stomatitis induced by
nicorandil could to be explain by a toxic effect, rather than a
toxicallergic or immunologic mechanism.
_____
Citation 2
Authors
Gigon S. Calonnec F. Kerbrat JB. Delcampe P. Peron JM.
Title
[A comparison of standard radiographs and "scout-view"
radiographs. The value for cephalometric analysis]. [French]
Original Title
Comparison des telecranes et des "modes radios". Interet
pour le bilan cephalometrique.
Source
Revue de Stomatologie et de Chirurgie Maxillo-Faciale. 99(4):181-3, 1998
Nov.
Abstract
Is the scout-view as reliable as the standard lateral view for cephalometric
analysis? Cephalometric data (Delaire analysis) were obtained in ten
patients with CT-scan and standard x-ray for comparison. Qualitative results
showed imprecisions for craniofacial contours and soft tissue ptosis.
Quantitative results were analyzed statistically and revealed a
significantly higher level of error with scout-view tracings. The scout-view
does not appear to be as reliable and takes longer to acquire than the
standard lateral x-ray: for the pediatric population, it could be a
disadvantage.
_____
Citation 3
Authors
Soriani O. Foll FL. Roman F. Monnet FP. Vaudry H. Cazin L.
Title
A-Current down-modulated by sigma receptor in frog pituitary melanotrope
cells through a G protein-dependent pathway.
Source
Journal of Pharmacology & Experimental Therapeutics. 289(1):321-8, 1999 Apr.
Abstract
Gramicidin perforated patch-clamp recordings were used to study the effects
of two sigma 1 receptor ligands, (+)-N-cyclopropylmethyl-N-methyl-1,
4-diphenyl-1-ethyl-but-3-en-1-ylamine hydrochloride (JO 1784) and
(+)-pentazocine, on the transient outward potassium current (IA) in cultured
frog melanotrope cells. (+)-Pentazocine reversibly decreased the current
amplitude in a dose-dependent manner. The effects of (+)-pentazocine were
mimicked by JO 1784 and were markedly reduced by the sigma 1 receptor
antagonist, N, N-dipropyl-2-[4-methoxy-3-2(2-phenylethoxy)phenyl]-ethylamine
monohydrochloride (NE 100). Inactivation rate of IA was best fitted with a
double exponential function, yielding time constants of 23.7 and 112.5 ms.
(+)-Pentazocine (20 microM) accelerated the current decay, decreasing the
time constants to 10.7 and 59 ms, respectively. Current-voltage experiments
revealed that (+)-pentazocine (20 microM) did neither modify the open-state
I/V curves nor the voltage dependence of IA. However, (+)-pentazocine (20
microM) shifted the steady-state inactivation curve toward more negative
potentials and increased the time constant of the time-dependent removal of
inactivation. In whole-cell experiments, internal dialysis of
guanosine-5'-O-(3-thiophosphate) (100 microM) irreversibly prolonged the
response to (+)-pentazocine. In addition, cholera toxin pretreatment (1
microgram. ml-1; 12 h) suppressed the inhibition of IA by (+)-pentazocine
(20 microM). It is concluded that in frog melanotrope cells, a cholera
toxin-sensitive, G protein-dependent inhibition of IA through a sigma 1
receptor activation, at least partially, underlies the excitatory effect of
sigma ligands.
_____
Citation 4
Authors
Gangnon F. Danger JM. Jegou S. Vieau D. Seidah NG. Vaudry H.
Title
Molecular cloning, characterization of cDNA, and distribution of mRNA
encoding the frog prohormone convertase PC1.
Source
Journal of Comparative Neurology. 405(2):160-72, 1999 Mar 8.
Abstract
Prohormone convertases (PCs) are calcium-dependent serine endoproteases of
the subtilisin/kexin family that play a key role in the posttranslational
processing of precursors for biologically active peptides. In this study, we
have characterized the cDNA encoding PC1 in the European green frog Rana
ridibunda. A frog brain cDNA library was screened by using a heterologous
probe at low stringency, and a 2.3-kb cDNA clone encoding PC1 was isolated.
This cDNA encodes a 736-residue protein with a 26-amino-acid signal peptide.
Comparative structural analysis revealed that frog PC1 exhibits a high
degree of amino acid identity with its mammalian counterparts, in particular
in the subtilisin-like catalytic domain. Northern blot analysis resolved two
major transcripts of 3.0 kb and 5.0 kb that were expressed differentially in
the brain and pituitary. In situ hybridization studies showed that, in the
frog brain, the highest densities of PC1 mRNA are present in the amygdala,
the hypothalamus, and the anterior preoptic area. High concentrations of PC1
mRNA also were found in the pars distalis and pars intermedia of the
pituitary, whereas the pars nervosa was devoid of hybridization signal. The
wide distribution of PC1 mRNA in the brain and pituitary suggests that, in
frog, PC1 is involved in the processing of a number of hormone and
neuropeptide precursors.
_____
Citation 5
Authors
Frebourg NB. Cauliez B. Lemeland JF.
Title
Evidence for nasal carriage of methicillin-resistant staphylococci
colonizing
intravascular devices.
Source
Journal of Clinical Microbiology. 37(4):1182-5, 1999 Apr.
Abstract
Nasal surveillance cultures were performed for 54 patients exhibiting
>/=10(3) CFU of methicillin-resistant coagulase-negative staphylococci per
ml in central venous catheter (CVC) rinse cultures over a 6-month period.
Forty-two of the nasal cultures yielded growth of methicillin-resistant
coagulase-negative staphylococci, and 33 of the 42 cultures contained
organisms that belonged to the same species as the CVC isolates. Of the 33
same-species isolates, 20 appeared to be identical strains by pulsed-field
gel electrophoresis analysis. These data suggest that measures should be
taken to reduce cross-contamination between the respiratory tract and
intravascular devices. However, the potential interest in detecting
methicillin-resistant coagulase-negative staphylococcus carriage in
high-risk patients is hampered by the lack of sensitivity of nasal
surveillance cultures.
_____
Citation 6
Authors
Baranzelli MC. Patte C. Bouffet E. Quintana E. Portas M. Vannier JP. Thyss
A. Schmitt C. Flamant F.
Title
[Malignant non-seminomatous germinal tumors of the ovary. Experience of the
French Society of Pediatric Oncology. 64 cases]. [French]
Original Title
Les tumeurs germinales malignes non seminomateuses de l'ovaire. Experience
de
la Societe Francaise d'Oncologie Pediatrique. A propos de 64 cas.
Source
Contraception, Fertilite, Sexualite. 27(2):133-9, 1999 Feb.
Abstract
Ovary seminomatous malignant germ cell tumours are a particular
histopathologica entity. The presence of yolk salk tumor or choriocarcinoma
is respectively correlated with elevation of alpha FP or beta hCG. This
markers elevation permits to assess diagnosis, appreciate response to
treatment, and detect relapses. The study of 64 patients registered in two
successive S.F.O.P. protocols (TGM 85-TGM 90) precise indications of
surgery, platin-based chemotherapy and results. Malignant non seminomatous
germ cell tumors are separated in not secreting pure immature teratoma and
secreting malignant germ cell tumours. Surgery is essential for treatment of
not secreting pure immature teratoma. Secreting germ cell tumors are very
chemosensitive and surgery must be as conservative as possible in all cases
even metastatic tumour or relapse. If markers are normalized second-look
surgery of secreting malignant germ cell tumours is only necessary in case
of evident residual tumour. However in case of initial chemotherapy,
resection of a pathological ovary is always performed at the end of
treatment. These tumours have a good prognosis: 5-years overall survival and
disease-free survival are 85%.
_____
Citation 7
Authors
Rives N. Wust S. David B. Duchesne V. Joly G. Mace B.
Title
Fluorescence in situ hybridization with chromosome paint probes: a novel
approach to assess aneuploidy in human sperm nuclei.
Source
Journal of Assisted Reproduction & Genetics. 16(1):46-51, 1999 Jan.
Abstract
PURPOSE: Fluorescence in situ hybridization (FISH) using whole-chromosome
paint probes was performed to evaluate disomy and diploidy frequency for
chromosomes 1, 18, 19, and 22 in human sperm nuclei. METHODS: Ten subjects
of proven fertility and normal spermatic parameters were included in the
study. A dual-color FISH method was carried out. RESULTS: A total of 157,896
spermatozoa was scored. The mean frequencies of disomic sperm for
chromosomes 1, 18, 19, and 22 were 0.22% (range, 0.19 to 0.28%), 0.24%
(range, 0.14 to 0.37%), 0.22% (range, 0.17 to 0.30%), and 0.25% (range, 0.21
to 0.29%), respectively. The mean frequency of diploidy was 0.14% (range,
0.09 to 0.18%). No interindividual and interchromosomal variations in the
aneuploidy frequency were observed between the different subjects.
CONCLUSIONS: FISH with whole-chromosome paint probes provides a novel and
efficient approach for disomy assessment in human sperm nuclei.
_____
Citation 8
Authors
Bouchart F. Bessou JP. Tabley A. Redonnet M. Mouton-Schleifer D.
Haas-Hubscher C. Soyer R.
Title
Urgent surgical repair of postinfarction ventricular septal rupture: early
and late outcome.
Source
Journal of Cardiac Surgery. 13(2):104-12, 1998 Mar.
Abstract
AIM: This retrospective analysis focuses on predictive factors of operative
mortality and long-term survival after surgical repair of postinfarction
ventricular septal rupture (VSR). METHODS: Sixty-seven patients (43 males,
24 females) with VSR underwent surgical repair between December 1977 and
December 1995. The site of the rupture was anterior in 44 patients and
posterior in 23. The mean interval between myocardial infarction (MI) and
VSR was 3.6+/-4.1 days. Clinical condition on admission was critical in 63
patients (49 in cardiogenic shock). An intra-aortic balloon pump was
inserted preoperatively in 54 patients. RESULTS: Operative mortality was 25%
(17 patients). The main cause of death was cardiac failure. Factors
influencing early deaths in univariate analysis were preoperative
hemodynamic status (cardiogenic shock present in 30%; absent in 8%; p =
0.001), the location of the MI (anterior in 11.6%, posterior in 45.4%), the
interval between infarction and surgery (<1 week was 33%, >1 week was 6.2%),
and the response to initial active therapy. All patients were available for
follow-up. The actuarial survival rates at 1 and 5 years are 74.6%+/-5.3%
and 66.2%+/-6.2%, respectively. There were 12 late deaths and 40% were
cardiac related. Two patients presented residual VSD (one reoperation). The
left ventricular ejection fraction (LVEF) was mildly impaired in 9 patients.
Three patients had moderate mitral insufficiency and two had moderate
tricuspid insufficiency. CONCLUSION: Repair of the postinfarction VSR
remains a challenge. Improvement should be rendered possible by optimizing
techniques. Postoperative morbidity is high, and these patients require
intensive hospital resources. The late results have been satisfactory.
_____
Citation 9
Authors
Hammoumi S. Payen A. Favre JD. Balmes JL. Benard JY. Husson M. Ferrand JP.
Martin JP. Daoust M.
Title
Does the short variant of the serotonin transporter linked polymorphic
region
constitute a marker of alcohol dependence?.
Source
Alcohol. 17(2):107-12, 1999 Feb.
Abstract
The serotonin (5-hydroxytryptamine: 5-HT) system has been thought to play an
important role in several steps of alcohol craving. A number of studies,
including our own, have reported that alcohol dependence is associated with
dysfunction of 5-HT transmission. Pharmacological and clinical studies have
shown that the 5-HT transporter (5-HTT) and the 5-HT1A receptor appear to be
candidate loci for the aetiology of alcohol dependence. We have analysed the
presence of different 5-HTT and 5-HT1A variants in 104 alcohol-dependent
patients and 38 controls for a possible association with alcohol dependence.
In alcohol-dependent patients, we found a high frequency of the S allele of
5-HTTLPR (45.5% vs. 29%, chi2 = 6.33, p = 0.0081). No other significant
differences were observed between the two populations for other
polymorphisms. These results provide, for the first time, preliminary
evidence that alcohol abuse disorders are associated with a genetic variant
for 5-HT transmission. It might be possible to use this detection of the "S"
allele as a clinical tool for pathology diagnosis and to advise recovering
alcoholics and it could represent an aid to the prevention of relapse.
Therapeutic actions could be envisaged to use this genotyping to help select
the best therapeutic strategy.
_____
Citation 10
Authors
Goudemand J. Peynet J. Chambost H. Negrier C. Briquel ME. Claeyssens S.
Derlon-Borel A. Guerois C. Caron C. Scherrmann JM. Debray M. Bridey F.
Title
A cross-over pharmacokinetic study of a double viral inactivated factor IX
concentrate (15 nm filtration and SD) compared to a SD factor IX
concentrate.
Source
Thrombosis & Haemostasis. 80(6):919-24, 1998 Dec.
Abstract
A double blind randomized cross-over multi-center study has been conducted
to compare the pharmacokinetic and coagulation activation markers of
high-purity factor IX concentrate subjected to both solvent/ detergent (SD)
treatment and 15 nm-filtration (FIX-SD-15) with the licensed product
subjected only to solvent-detergent (FIX-SD). This filtration process allows
the elimination of small particles, such as non-enveloped viruses (i.e.,
hepatitis A and parvovirus B19). Eleven severe hemophilia B patients (FIX
coagulant activity <2 IU/dl) received one infusion of 60 IU/kg of FIX-SD and
one infusion of 60 IU/kg of FIX-SD-15 at least at 10 days interval. Blood
samples were obtained before and at various time up to 72 h after infusion.
The decay curves of factor IX (FIX:C and FIX:Ag) were evaluated by a model
independent method. Bioequivalence was found between the two concentrates
using the Schuirmann test. The mean FIX:C and FIX:Ag recovery of FIX-SD-15
was 1.08 and 0.89 IU/dl/IU/kg respectively with a mean half-life of 33.3 h
for FIX:C and 25.6 h for FIX:Ag. Six months after initial enrollment,
pharmacokinetic parameters were similar in the 7 patients tested. There was
no significant variation of prothrombin fragment 1+2 and
thrombin-antithrombin complexes measured up to 6 h after infusion,
indicating that there was no activation process after administration of FIX.
In conclusion, these data demonstrate that the introduction of a 15 nm
filtration does not alter the pharmacokinetic profile of a well
characterized SD FIX concentrate while providing additional viral safety.
_____
Citation 11
Authors
Gail MH. Pee D. Benichou J. Carroll R.
Title
Designing studies to estimate the penetrance of an identified autosomal
dominant mutation: cohort, case-control, and genotyped-proband designs.
Source
Genetic Epidemiology. 16(1):15-39, 1999.
Abstract
One can obtain population-based estimates of the penetrance of a measurable
mutation from cohort studies, from population-based case-control studies,
and from genotyped-proband designs (GPD). In a GPD, we assume that
representative individuals (probands) agree to be genotyped, and one then
obtains information on the phenotypes of first-degree relatives. We also
consider an extension of the GPD in which a relative is genotyped (GPDR
design). In this paper, we give methods and tables for determining sample
sizes needed to achieve desired precision for penetrance estimates from such
studies. We emphasize dichotomous phenotypes, but methods for survival data
are also given. In an example based on the BRCA1 gene and parameters given
by Claus et al. [(1991) Am J Hum Genet 48:232-242], we find that similar
large numbers of families need to be studied using the cohort, case-control,
and GPD designs if the allele frequency is known, though the GPDR design
requires fewer families, and, if one can study mainly probands with disease,
the GPD design also requires fewer families. If the allele frequency is not
known, somewhat larger sample sizes are required. Surprisingly, studies with
mixtures of families of affected and non-affected probands can sometimes be
more efficient than studies based exclusively on affected probands when the
allele frequency is unknown. We discuss the feasibility and validity of
these designs and point out that GPD and GPDR designs are more susceptible
to a bias that results when the tendency for an individual to volunteer to
be a proband or to be a subject in a cohort or case-control study depends on
the phenotypes of his or her relatives.
_____
Citation 12
Authors
Contesse V. Breault L. Yon L. Delarue C. Lefebvre H. Gallo-Payet N. Vaudry
H.
Title
Ontogeny of 5-HT4 receptors in the human adrenal gland.
Source
Endocrine Research. 24(3-4):933-4, 1998 Aug-Nov.
_____
Citation 13
Authors
Lefebvre H. Gonzalez KN. Contesse V. Delarue C. Vaudry H. Kuhnl JM.
Title
Effect of prolonged administration of the serotonin4 (5-HT4) receptor
agonist
cisapride on aldosterone secretion in healthy volunteers.
Source
Endocrine Research. 24(3-4):749-52, 1998 Aug-Nov.
Abstract
In man, serotonin (5-HT) has been shown to stimulate aldosterone secretion
through activation of 5-HT4 receptors, In particular, we have observed that
oral administration of a single dose of the 5-HT4 receptor agonist cisapride
(10 mg) induces a 5-fold increase in plasma aldosterone levels in healthy
volunteers. Surprisingly, the usual disorders associated with
hyperaldosteronism, i.e. hypertension and hypokalemia, have never been
reported during chronic treatment with cisapride. In the present study, we
have investigated the effect of prolonged oral administration of cisapride
(10 mg, 3 times/day during 7 days) on aldosterone secretion in 12 healthy
volunteers, in a simple blind fashion versus placebo. On day 1 of the
treatment, cisapride induced a significant increase in plasma aldosterone
levels (PAL) which returned to the values observed after placebo treatment
within 10 hrs. On days 2 and 3, PAL were similar in cisapride- and
placebo-treated subjects. Urinary aldosterone, kalemia and reninemia were
not influenced by cisapride during the 7 days of the treatment. The present
study shows that cisapride only exerts a transient stimulatory effect on
aldosterone secretion in healthy volunteers. These data explain why
long-term administration of 5-HT4 agonists does not affect blood pressure in
man. They also indicate that prolonged stimulation of adrenal 5-HT4
receptors in vivo yields to a rapid desensitization phenomenon, as
previously observed in vitro.
_____
Citation 14
Authors
Anouar Y. Yon L. Desmoucelles C. Leprince J. Breault L. Gallo-Payet N.
Vaudry H.
Title
Identification of a novel secretogranin II-derived peptide in the adult and
fetal human adrenal gland.
Source
Endocrine Research. 24(3-4):731-6, 1998 Aug-Nov.
Abstract
Molecular cloning of secretogranin II (SgII) in different species has
revealed the existence of a highly conserved 66-amino acid peptide (EM66)
flanked by preserved pairs of basic residues. In the present study we have
localized and characterized EM66 in the human adrenal gland. A fusion
protein containing the human EM66 peptide was produced in E. coli and used
to raise polyclonal antibodies in rabbits. Immunohistochemical staining of
human adrenal slices revealed intense labeling of adrenochromaffin cells in
the adult and fetal gland. HPLC analysis of adrenal extracts showed the
presence of an immunoreactive peak exhibiting the same retention time as
recombinant EM66 in both adult and fetus. These data demonstrate that
post-translational processing of SgII actually generates a novel peptide in
the human adrenal gland. The conservation of the sequence of EM66 in
vertebrates and the occurrence of the mature peptide during early
ontogenesis of the human adrenal gland strongly suggest that EM66 could
exert physiological activities.
_____
Citation 15
Authors
Delarue C. Contesse V. Lefebvre H. Lenglet S. Grumolato L. Kuhn JM. Vaudry
H.
Title
Pharmacological profile of serotonergic receptors in the adrenal gland.
Source
Endocrine Research. 24(3-4):687-94, 1998 Aug-Nov.
Abstract
The secretory activity of the adrenal gland is mainly regulated by
peptidergic hormones (ACTH, angiotensin II) and ions. However, there is now
increasing evidence that local factors, including neuropeptides and
neurotransmitters, can also participate in the control of adrenocortical
cells. In particular, serotonin (5-HT), produced by adrenochromaffin cells
in frog and rat as well as by mast cells in the adrenal gland of rat and
human, stimulates corticosteroid secretion. In both frog and human adrenal
gland, the benzamide derivative (R,S)-zacopride induces a robust increase in
corticosteroid release suggesting that the effect of 5-HT on steroidogenesis
is mediated through activation of 5-HT4 receptors. In contrast, in rat, the
stimulatory effect of 5-HT on aldosterone secretion is clearly not mediated
by 5-HT4 receptors. In all three species, incubation of adrenocortical
fragments with 5-HT induces a significant increase in cAMP formation. Our
data suggest that 5-HT, released within the adrenal cortex, may act as a
paracrine factor to stimulate steroid secretion. Although the corticotropic
effect of 5-HT has been conserved from amphibians to primates, the type of
receptors involved in the action of 5-HT markedly differs across species.
_____
Citation 16
Authors
Tollemer H. Teitsma CA. Leprince J. Bailhache T. Vandesande F. Kah O. Tonon
MC. Vaudry H.
Title
Immunohistochemical localization and biochemical characterization of two
novel decapeptides derived from POMC-A in the trout hypothalamus.
Source
Cell & Tissue Research. 295(3):409-17, 1999 Mar.
Abstract
Several vertebrate species which underwent duplication of their genome, such
as trout, salmon and Xenopus, possess two proopiomelanocortin (POMC) genes.
In the trout, one of the POMC molecules, called POMC-A, exhibits a unique
C-terminal extension of 25 amino acids which has no equivalent in other
POMCs characterized so far. This C-terminal peptide contains three pairs of
basic residues, suggesting that it may be the source of novel regulatory
peptides. The aim of the present study was to investigate the occurrence of
these peptides in the brain of the trout Oncorhynchus mykiss by using
specific antibodies raised against two epitopes derived from the C-terminal
extension of POMC-A, i.e., EQWGREEGEE and YHFQ-NH2. Immunohistochemical
labeling of brain sections revealed the presence of EQWGREEGEE- and
YHFQ-NH2-immunoreactive cell bodies in the anterior part of the nucleus
lateralis tuberis of the hypothalamus. Immunoreactive fibers were observed
in the dorsal hypothalamus, the thalamus, the telencephalon, the optic
tectum and the medulla oblongata. In contrast, no labeling was detected
using antibodies against the non-amidated peptide YHFQG. Biochemical
characterization was performed by combining high-performance liquid
chromatography (HPLC) analysis with radioimmunoassay (RIA) quantification.
Two peptides exhibiting the same retention time as synthetic EQWGREEGEE and
ALGERKYHFQ-NH2 were resolved. However, no peptide co-eluting with YHFQ-NH2
or YHFQG could be detected. These results demonstrate that, in the trout
brain, post-translational processing of POMC-A generates the two
decapeptides EQWGREEGEE and ALGERKYHFQ-NH2. The wide distribution of
immunoreactive fibers in the diencephalon, telencephalon, optic tectum and
medulla oblongata suggests that these peptides may exert neurotransmitter
and/or neuromodulator activities.
_____
Citation 17
Authors
Garcia de Mateos-Verchere J. Vaugeois JM. Naudin B. Costentin J.
Title
Behavioural and neurochemical evidence that the antimicrobial agent oxolinic
acid is a dopamine uptake inhibitor.
Source
European Neuropsychopharmacology. 8(4):255-9, 1998 Dec.
Abstract
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose
dependent increase in locomotor activity. This stimulation culminated at the
32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When
opposed to increasing doses (50-100-200 microg/kg i.p.) of haloperidol (D2
dopamine receptor antagonist), the stimulant locomotor effect of 32 mg/kg
oxolinic acid was not significantly reversed. On the contrary increasing
doses (7.5-15-30 microg/kg s.c.) of SCH 23390 (D1 dopamine receptor
antagonist) inhibited the stimulant locomotor effect. In mice made
completely akinetic by a pretreatment with reserpine (4 mg/kg s.c., 18 h
before testing), dexamphetamine (2 mg/kg s.c.) reversed this akinesia and
even displayed a stimulant activity, similar to that observed in mice not
treated by reserpine. On the contrary, oxolinic acid (32 mg/kg) did not
reverse the reserpine induced akinesia and even opposed the reversion
induced by dexamphetamine. In a synaptosomal fraction prepared from striatum
of rats, oxolinic acid inhibited the 3H dopamine uptake with an IC50 =
4.3+/-0.6 x 10(-6) M. Finally, in mice injected i.v. with a tracer dose of
3H WIN 35428 (1 microCi) (a dopamine uptake blocker), 32 mg/kg oxolinic
acid, i.p. administered, reduced by about 50% the specific binding of the
radioligand to striatal dopamine carriers. It is concluded that the
stimulant locomotor effect of oxolinic acid depends on the blockade of the
neuronal dopamine uptake complex.
_____
Citation 18
Authors
Saoudi N. Appl U. Anselme F. Voglimacci M. Cribier A.
Title
How smart should pacemakers Be?. [Review] [32 refs]
Source
American Journal of Cardiology. 83(5B):180D-186D, 1999 Mar 11.
Abstract
The concept of the "smart" pacemaker has been continuously changing during
40 years of progress in technology. When we talk today about smart
pacemakers, it means optimal treatment, diagnosis, and follow-up for
patients fitting the current indications for pacemakers. So what is smart
today becomes accepted as "state of the art" tomorrow. Originally,
implantable pacemakers were developed to save lives from prolonged episodes
of bradycardia and/or complete heart block. Now, in addition, they improve
quality of life via numerous different functions acting under specific
conditions, thanks to the introduction of microprocessors. The devices have
become smaller, with the miniaturization of the electrical components,
without compromising longevity. Nevertheless, there are still some unmatched
objectives for these devices, for example, the optimization of cardiac
output and the management of atrial arrhythmias in dual-chamber devices.
Furthermore, indications continue to evolve, which in turn require new,
additional functions. These functions are often very complex, necessitating
computerized programming to simplify application. In addition, the follow-up
of these devices is time-consuming, as appropriate system performance has to
be regularly monitored. A great many of these functions could be
automatically performed and documented, thus enabling physicians and
paramedical staff to avoid losing time with routine control procedures. In
addition, modern pacemakers offer extensive diagnostic functions to help
diagnose patient symptoms and pacemaker system problems. Different types of
data are available, and their presentation differs from one company to the
other. This huge amount of data can only be managed with automatic
diagnostic functions. Thus, the smart pacemaker of the near future should
offer high flexibility to permit easy programming of available therapies and
follow-up, and extensive, easily comprehensible diagnostic functions.
[References: 32]
_____
Citation 19
Authors
Mensah-Nyagan AG. Do-Rego JL. Beaujean D. Luu-The V. Pelletier G. Vaudry H.
Title
Neurosteroids: expression of steroidogenic enzymes and regulation of steroid
biosynthesis in the central nervous system. [Review] [298 refs]
Source
Pharmacological Reviews. 51(1):63-81, 1999 Mar.
_____
Citation 20
Authors
Lambert V. Blaysat G. Sidi D. Lacour-Gayet F.
Title
Double-lumen aortic arch by persistence of fifth aortic arch: A new case
associated with coarctation. [Review] [14 refs]
Source
Pediatric Cardiology. 20(2):167-9, 1999 Mar-Apr.
Abstract
A coarctation of aorta with double-lumen aortic arch due to persistence of
an embryonic fifth aortic arch was recognized in a 13-day-old girl and
successfully repaired using enlargement of the aorta by side-to-side
anastomosis of the fourth and fifth aortic arches. [References: 14]
_____
Citation 21
Authors
Ducrotte P.
Title
[Treatment of gastroesophageal reflux: life style-dietetic rules and topical
agents]. [Review] [83 refs] [French]
Original Title
Traitement du reflux gastro-oesophagien: regles hygieno-dietetiques et
topiques.
Source
Gastroenterologie Clinique et Biologique. 23(1 Pt 2):S70-7, 1999 Jan.
_____
Citation 22
Authors
Colin R.
Title
[Diagnostic strategy in gastroesophageal reflux and therapeutic test].
[Review] [49 refs] [French]
Original Title
Strategie diagnostique du reflux gastro-oesophagien et test therapeutique.
Source
Gastroenterologie Clinique et Biologique. 23(1 Pt 2):S37-44, 1999 Jan.
_____
Citation 23
Authors
Guedon C.
Title
[How to diagnose gastroesophageal reflux? Part 1. Diagnostic value of
symptoms. Interpretation and role of endoscopy]. [Review] [53 refs] [French]
Original Title
Comment diagnostiquer un RGO? 1re partie: valeur semiologique des symptomes.
Interpretation et place de l'endoscopie.
Source
Gastroenterologie Clinique et Biologique. 23(1 Pt 2):S202-7, 1999 Jan.
_____
Citation 24
Authors
Mouterde O. Marie-Cardine A. Thiron JM. Mallet E.
Title
["Constipation" caused by maternal milk (letter)]. [French]
Original Title
A propos de la "constipation" au lait maternel.
Source
Archives de Pediatrie. 6(2):229, 1999 Feb.
_____
Citation 25
Authors
Rothschild C. Laurian Y. Satre EP. Borel Derlon A. Chambost H. Moreau P.
Goudemand J. Parquet A. Peynet J. Vicariot M. Beurrier P. Claeyssens S.
Durin A. Faradji A. Fressinaud E. Gaillard S. Guerin V. Guerois C. Pernod G.
Pouzol P. Schved JF. Gazengel C.
Title
French previously untreated patients with severe hemophilia A after exposure
to recombinant factor VIII : incidence of inhibitor and evaluation of immune
tolerance.
Source
Thrombosis & Haemostasis. 80(5):779-83, 1998 Nov.
Abstract
Fifty French previously untreated patients with severe hemophilia A (factor
VIII < 1%), treated with only one brand of recombinant factor VIII (rFVIII),
were evaluated for inhibitor development, assessment of risk factors and
outcome of immune tolerance regimen. The median period on study was 32
months (range 9-74) since the first injection of rFVIII. Fourteen patients
(28%) developed an inhibitor, four of whom (8%) with a high titer (> or = 10
BU). All inhibitor patients but one continued to receive rFVIII either for
on-demand treatment or for immune tolerance regimen (ITR). Among these
patients, inhibitor was transient in 2 (4%), became undetectable in 6 and
was still present in 6. The prevalence of inhibitor was 12%. Presence of
intron 22 inversion was found to be a risk factor for inhibitor development.
Immune tolerance was difficult to achieve in our series despite a follow-up
period of 16 to 30 months: immune tolerance was complete in only one out of
the 3 patients undergoing low dose ITR and in one out of the 5 patients with
high dose ITR.
_____
Citation 26
Authors
Savoye G. Hochain P. Riachi G. Scotte M. Herve S. Fraleu-Louer B. Chiron A.
Ducrotte P.
Title
Early massive bleeding after endoscopic ligation for junctional varices.
Source
Endoscopy. 30(9):S101, 1998 Nov.
